Spiroethers of German chamomile inhibit production of aflatoxin G1and trichothecene mycotoxin by inhibiting cytochrome P450 monooxygenases involved in their biosynthesis
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چکیده
منابع مشابه
Versatile biocatalysis of fungal cytochrome P450 monooxygenases
Cytochrome P450 (CYP) monooxygenases, the nature's most versatile biological catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a wide range of substrates under mild reaction conditions, thereby addressing a significant challenge in chemocatalysis. Though CYP enzymes are ubiquitous in all biological kingdoms, the divergence of CYPs in fungal kingdom is man...
متن کاملCloning of wound-induced cytochrome P450 monooxygenases expressed in pea.
Cytochrome P450 monooxygenases (P450s) mediate a wide range of oxidative reactions involved in the biosynthesis of plant secondary metabolites including phenylpropanoids and phytoalexins. To investigate the regulation of these P450s in the phenylpropanoid biosynthetic pathway of pea (Pisum sativum), partial cDNAs representing four distinct P450s expressed in pea seedlings were cloned using a re...
متن کاملThe role of cytochrome P450 monooxygenases in plant-insect interactions.
Plants and herbivorous insects interact at the most fundamental of levels. With few exceptions, in the battle waged daily between these two groups of organisms, one serves as food source, the other as consumer. From a plant’s perspective, success in this interaction is measured by its ability to defend itself from devastation by insect feeding. From an insect’s perspective, success is measured ...
متن کاملDiversity and evolution of cytochrome P450 monooxygenases in Oomycetes
Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred and fifty-six P450s were found in oomycetes. These P450s were grouped into 15...
متن کاملMolecular genetics of the human cytochrome P450-dependent monooxygenases.
In this work, the role of genetic as well as environmental factors in determining cytochrome P450 isozyme levels in man have been studied. Simple DNA based assays for the identification of individuals nulled at the CYP2D6 locus are described and have been applied to investigate whether this gene defect is associated with altered cancer susceptibility. In contrast to literature reports, in no ca...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2008
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.2008.01195.x